Endocrine Abstracts

Introduction: Treatment of hypothyroidism with levothyroxine is effective and simple; however, international guidelines advise starting with low doses in case of severe hypothyroidism, cardiac illness and aged population. Interestingly, and in contradiction to this dogma, high doses of levothyroxine have been given to patients with myxedema coma without untoward effects. The difference between myxedema coma, which deserves an intensive treatment, and longstanding severe hypoth...

Introduction: Maternal clinical thyroid disorders can cause reproductive complications. However, the effects of mild thyroid dysfunction are controversial. The impact of SH and thyroid autoimmunity on miscarriages, obstetric and perinatal outcomes are not yet well established and the effect of levothyroxine replacement in pregnant women with SH is unclear. The aim of this study was to evaluate the impact of thyroid autoimmunity in early pregnancy on obstetric and perinatal out...

Background and objective: Papillary thyroid microcarcinoma (PTMC) is recognized as a separate entity by the World Health Organization. Biological behaviour and clinical outcomes of PTMC are heterogenous. Presence of lymph node metastases (LNM) in this group of patients increases the risk of recurrence and makes optimal management in PTMC controversial (observation, lobectomy with or without preventive central ipsilateral dissection). The aim of this study was to describe risk ...

Introduction: To date, benign thyroid nodules complainig of symptomatic or cosmetic problems and autonomous functioning thyroid nodules (AFTN) have generally been treated with surgery or I131. Radiofrequency ablation (RFA) is a novel technique that has demonstrated safety and efficacy in the treatment of these nodules. We describe the clinical experience at our hospital.Material and method: We include 33 patients (28 women, 5 men) from January 2013 to Se...

Introduction: While iatrogenic Cushing’s syndrome is common, acquired isolated ACTH deficiency is a rare condition. Hypophysitis is the most common cause, and while most recently published cases are associated with immunotherapy, it may also be idiopathic. Hereby we present a case of cortical adrenal atrophy secondary to idiopathic acquired ACTH deficiency, in order to raise awareness about this condition.Material and Methods: Review of the patient&...

Aim: Description of a series of children and adolescents with Primary Aldosteronism (PA) diagnosed and treated in our Outpatient Hypertension Clinic from 1994 to 2018.Methods: Review of the clinical records and of the relevant literature. Values are given as mean +s.d.Results: 16 of a total of 49 patients younger than 20 years of age referred to our Hypertension Clinic from 1994 to 2018 were diagnosed of PA (33%), while 27 (55%) we...

Introduction: Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency (classic 21-OHD CAH) is the most common form of congenital adrenal hyperplasia, characterized by simple virilizing or salt wasting forms. The saline loss picture develops after birth and it can evolve in a short time to a severe picture of hypotonic dehydration and hypovolemic shock with lethal consequences if not diagnosed and treated. Herein we present an unusual case of classic 21-OHD CAH ...

Introduction: A new subtype of diabetes, ketosis-prone diabetes (KPD) has been described in the last years among African, Asian and Hispanic population with characteristics similar to type 1 diabetes (DM1) such as cardinal symptoms, tendency to ketosis and decreased pancreatic reserve at onset, but with negative autoimmunity. The aim of this study was to compare this type of patients with those with type 1 diabetes at onset and their evolution.Material a...

Aim: Comparing the effect of Faster Aspart insulin (Fiasp®) with previous insulin analogues (aspart, lispro) in type I diabetic patients with sensor-augmented pump therapy.Methods: Patients with Minimed Paradigm® insulin pumps, Enlite® sensors and Guardian® software (able to automatically stop the pump infusion to prevent hypoglycemia) were switched from previous insulin to Faster Aspart. Da...

Introduction/Aim: Transgender people often worry about side effects of their hormonal therapy, including breast cancer, which is an exceedingly rare occurrence. Hereby we present the case of a patient with an uncommon metadiabetic complication that can be easily confused with breast cancer, with the aim of raising awareness on this condition.Material and Methods: Review of the Clinical Record of the patient and of the relevant literature.<p class="ab...